Centre for Plant-Derived, Nanoemulsion-Based Cancer Drug Discovery
Principal Investigator
Prof. R. Nagarajan
Objective
- To identify the best-suited carcinoma cell lines where Indian spice-derived nanoemulsions would work with the highest affinity, To use scientific evidence to identify the molecular mechanisms behind the anticancer activity, To validate the cell-line findings via animal trials and via toxicity and pharmacokinetic studies
Description
- Plant-based essential oils ? with age-old demonstrated efficacy in pharmaceutical applications ? offer innovative alternatives to synthetic drugs, paving the way for this IIT Madras initiative that pioneers cancer drug discovery using Indian spice-derived nanoemulsions. By identifying best-suited carcinoma cell lines, uncovering molecular mechanisms of anticancer activity, and validating findings through animal trials and pharmacokinetic studies, the project aims to overcome toxic side-effects of current treatments ? delivering cost-effective, safer oncology therapies to India's large and diverse patient population within 5?10 years.
Impact
- The toxic side-effects experienced by many when undergoing today's approved cancer treatments could conceivably be overcome by the proposed work, Established contacts and engaged in preliminary discussions with two Indian pharmaceutical companies
Budget in Lakhs
475.65
Duration
3 years