2-D Electronic Spectroscopy of photodynamic Therapeutic Drug Molecules
Principal Investigator
Prof. Krishna Reddy Nandipatti
Objective
- The proposed project aims to describe the 2DES of ZnPCs using first-principles computational methods.
Description
- Of the treatments for cancer available today, photodynamic therapy (PDT) is a minimally invasive treatment for certain types of cancer., Understanding the photochemical mechanisms of action of promising drugs is essential for improvements of PDT. In this context, zinc phthalocyanine (ZnPC) and its derivatives have been identified as excellent photosensitizers, but their mechanism of action is poorly understood, in part due to fundamental limitations of conventional spectroscopy., Two-dimensional electronic spectroscopy (2DES) is a recent experimental breakthrough in capturing electronic and nuclear changes during the course of ultrafast molecular processes to an unprecedented level of detail.
Impact
- The results coming out of the project can be applied to further research in the field to investigate large-size derivatives of ZnPCs., The nature of the proposed project would promote experimental collaborations., With the CSR Grant, this project helps us establish a vibrant research group that is equipped with the required infrastructure and human resources to perform world-class research
Budget in Lakhs
30.00
Duration
3 Years