Development of affordable test system to detect uterus abnormalities in rural young women
Principal Investigator
Prof. Swathi Sudhakar
Objective
- Developing a lateral flow assay (LFA) diagnostic kit for endometriosis using Histone 4 as a biomarker involves a multi-step process that starts with the validation of the biomarker and synthesis of the detection elements.
Description
- Focusing on endometriosis is essential because it is a prevalent condition affecting 1 in 10 of reproductive-age women, often leading to chronic pain, infertility, and significant impacts on quality of life, mental health, and productivity. Despite its commonality, endometriosis is frequently underdiagnosed and misunderstood, resulting in delayed treatment and unnecessary suffering., The need for a noninvasive, simple, and affordable diagnostic kit to detect endometriosis is critical due to the challenges associated with current diagnostic methods.
Impact
- LFA based detection of endometriosis., ELISA based assays optimizing histone 4 and anti histone 4 interaction, AuNP conjugation with antibody., Development of LFA kit and validation using synthetic Histone 4., Validation of clinical samples.
Duration
12 Months