Concept Note on development of an affordable test system to detect uterus abnormalities in rural young women
Principal Investigator
Prof. Swathi Sudhakar
Objective
- Developing a lateral flow assay (LFA) diagnostic kit for endometriosis using Histone 4 as a biomarker involves a multi-step process that starts with the validation of the biomarker and synthesis of the detection elements.
Description
- Focusing on endometriosis is essential because it is a prevalent condition affecting 1 in 10 of reproductive-age women, often leading to chronic pain, infertility, and significant impacts on quality of life, mental health, and productivity. Despite its commonality, endometriosis is frequently underdiagnosed and misunderstood, resulting in delayed treatment and unnecessary suffering. Around 700 million women in the world have endometriosis.
Impact
- Parameters such as antibody concentrations, nanoparticle size, and blocking agents will be fine-tuned to minimize non-specific binding and enhance the sensitivity and specificity of the assay., Statistical analysis will be conducted to compare the LFA results with established diagnostic methods, such as laparoscopic examination.