Detection of DNA Biomarkers for Gastric Cancer Using P-Fab Platform

Detection of DNA biomarkers circulating in blood for gastric cancer detection using indigenously developed P-Fab platform

Objective

• We propose the development of a highly sensitive plasmonic fiber optic absorbance biosensor (P-FAB) for the ultra-sensitive detection of methylated cfDNA specific to gastric cancer.

Description

• Gastric cancer (GC) remains one of the leading causes of cancer-related mortality worldwide, largely attributed to delayed diagnosis and limited access to effective early screening strategies. A defining challenge in GC management is that early-stage disease is often asymptomatic or presents with non-specific clinical features. There is a pressing need for non-invasive, highly sensitive and scalable diagnostic technologies that can enable early GC detection. To address this critical gap, we propose the development of a highly sensitive plasmonic fiber optic absorbance biosensor (P-FAB) for the ultra-sensitive detection of methylated cfDNA specific to gastric cancer.

Impact

• Early, non-invasive gastric cancer detection., Affordable and sustainable screening solution., Reduction in long-term healthcare expenditure., Strengthening Aatmanirbhar Bharat and Make in India initiatives., Scalable indigenous diagnostic platform.