Degradation effects of diabetes on oral and systemic health evaluated by a novel customized handheld FT-IR
Principal Investigator
Prof. Tiju Thomas
Objective
- This study primarily aims to introduce a novel customized handheld FT-IR for the detection of advanced glycation end products namely Pentosidine (PEN), N-Carboxymethyl-lysine (CML), Methylglyoxal (MGO), Furosine and Glucosepane in the coronal dentin of patients with Type II mellitus by means of a chairside technique.
Description
- The prevalence of diabetes among adults (20-79 years of age) in India is 72.9 million. A phenomenal increase in diabetes in the last 10 years, from 40.9 million in 2007 to 72.9 million in 2017 (1.78- fold increase) occurred., With respect to the oral cavity, dentin is a mineralized tissue with high collagen content, does not turnover, and thus accumulates extracellular matrix modifications over a lifetime. Advanced glycation end products (AGES) can accumulate in dentin., Identification and a more detailed knowledge of the complexities of AGE-mediated cross-links will aid in the understanding of the biomechanical functional consequences to the dentin.
Impact
- To purchase an FTIR and conduct an invitro pilot study to assess the effects of AGES on mineralised dental tissues., Introduction of a customized handheld FT-IR for the identification of advanced glycation end products., To observe the effects of these advanced glycation end products., To assess the chemical characterization of enamel and dentin of patients