Microfluidic Platform for Early Sepsis Detection CSR Project

Microfluidic platform for early detection of sepsis

Objective

• To demonstrate the detection of multiple blood parameters using a microfluidic platform., To develop an integrated microfluidic platform for the simultaneous detection of multiple blood parameters online in real time., To validate the platform in an ICU setting by conducting large clinical trials., To develop an industrial prototype of the platform for possible commercialization.

Description

• One-third of all in-hospital patients, greater than 50% of all ICU patients, and more than 80% of surgical ICU patients suffer from sepsis-induced morbidity and mortality with diminishing chances of survival due to delayed diagnosis and poor prognosis., Microbial tests are time-consuming and the currently available biochemical markers lack specificity and can detect only at later stages of sepsis. Thus, early diagnosis of sepsis in acute trauma patients is mandatory for effective management., Recent studies have highlighted the importance of gasotransmitters in the detection and prognosis of sepsis due to their ability to predict immune-endothelial cross-talk. Thus, a point-of-care device for continuous and sensitive monitoring of the gasotransmitters along with other endothelial markers is essential for early prediction of sepsis.

Impact

• Continuous online monitoring system for detection of blood parameters in ICU patients., Predictive algorithms for prognosis of sepsis., IP and Licensing.