Molecular Dynamics Analysis on Alzheimer's Patients' Brains
Principal Investigator
Prof. M Hamsa Priya
Objective
- This project aims to unravel the complex relationship between sialic acid, a critical component for brain function, and the aggregation of amyloid-beta in Alzheimer's disease (AD). Through molecular simulations, we intend to investigate how sialic acid influences amyloid-beta plaque formation and gain insights into potential therapeutic strategies to inhibit disease progression.
Description
- Study the direct interaction of sialic acid with amyloid-beta peptides., Examine amyloid-beta aggregation in the presence of sialic acid., Evaluate the impact of gangliosides (sialic acid-containing lipids) on amyloid-beta aggregation., Utilize molecular dynamics simulations to understand the molecular mechanisms involved., Validate molecular models for sialic acid and gangliosides., Investigate binding sites and interaction strengths between sialic acid, gangliosides, and amyloid-beta., Assess the effects of sialic acid on amyloid-beta fibril formation.
Impact
- Alzheimer's disease poses a significant global health challenge with no known cure. This project holds the potential to provide critical insights into the role of sialic acid in amyloid-beta aggregation, a hallmark of AD. Understanding these molecular interactions could lead to the development of glycan-based therapeutics for inhibiting plaque formation. Such advancements are vital in the pursuit of effective treatments to alleviate the suffering of AD patients and reduce the burden on their families.
Budget in Lakhs
25.00
Duration
3 Years