Nanovesicle Multi-Drug Cancer Delivery CSR Project

Simultaneous delivery of multiple chemotherapeutic agents at specific tumor sites through engineerable nanovesicles (Equipment)

Objective

• in this proposal, a novel, biocompatible and inexpensive AOT based nano size vesicle for the co-delivery of Dox and Cur drugs has been proposed.

Description

• In this work, our starting hypothesis is that the simultaneous delivery of existing chemotherapeutic agents and a chemosensitizer to the cancer site could enhance the anticancer efficacy. In recent years, nano sized vesicles which are made up of nonionic amphiphilic molecules are widely used as a carrier in drug delivery applications due to their biocompatibility and easy membrane permeability. The AOT-based nanovesicles can simultaneously encapsulate both hydrophilic and hydrophobic drugs. This ability makes it a suitable candidate for combinatorial therapy.

Impact

• If successful, the proposed work will provide a novel approach to develop nanovesicles as a smart drug delivery to carry multiple cancer drugs to the specific tumour site.