Novel Low-Cost Anti-Malarial Compounds from Viola Odorata CSR Project

Identification of novel low-cost anti-malarials from viola odorata (Banafsha), an Indian medicinal plant used in AYUSH, against the artemisinin-resistant Plasmodium falciparum

Objective

• This project aims to identify low-cost anti-malarial compounds from Viola odorata, an Indian medicinal plant, specifically targeting artemisinin-resistant Plasmodium falciparum. The primary objectives include screening for potential anti-malarials, identifying key phytochemicals with anti-malarial properties, and characterizing the mechanisms of action of these compounds.

Description

• Culture P. falciparum strains for experimentation. Screen phytochemical extracts from Viola odorata for anti-malarial activity. Investigate mechanisms of action through proteomics analysis. Optimize in vitro cultures of Viola odorata for maximum biomass production. Compare the bioactivity of plant cell biomass extract with natural plant biomass. Study anti-plasmodial activity against various P. falciparum strains, including artemisinin-resistant ones.

Impact

• This project holds the potential to address the pressing issue of drug-resistant malaria by identifying novel, low-cost anti-malarial compounds from Viola odorata. The outcomes of this research may lead to the development of effective treatments against artemisinin-resistant Plasmodium falciparum strains, significantly contributing to global malaria control efforts. Additionally, this work aligns with Sustainable Development Goal III by focusing on the eradication of epidemics like malaria and underscores the importance of exploring traditional herbal medicines for public health.