Multi-omic analysis to identify the mutational landscape, biomarkers and novel drug targets for Pancreatic cancer of Indian cohorts
Principal Investigator
Prof. S. Mahalingam
Objective
- The objective of this proposal is to perform a comprehensive multi-omic analysis, including whole-exome and transcriptome sequencing, of pancreatic cancer in Indian cohorts. The aim is to identify specific biomarkers for early detection and novel drug targets to improve therapeutics for this lethal disease, which currently lacks effective diagnostic markers and targeted treatments in the Indian population.
Description
- Comprehensive Genomic Analysis: Perform whole-exome sequencing and RNA sequencing on 50 pancreatic cancer samples, along with matched normal tissue samples, from Indian cohorts. This analysis will reveal mutational mechanisms and candidate genomic events driving pancreatic carcinogenesis., Identification of Biomarkers: Identify specific biomarkers for early detection of pancreatic cancer based on the differential expression profile and mutational landscape obtained from the genomic analysis., Novel Drug Targets: Select significantly deregulated genes for developing targeted next-generation sequencing (NGS) panels or antibody-based detection assays as potential drug targets.
Impact
- This proposal's impact lies in its potential to transform pancreatic cancer management in India by identifying population-specific biomarkers and drug targets. Early detection and personalized therapeutics could significantly improve survival rates, addressing a critical healthcare need and fostering international collaborations in cancer research.
Budget in Lakhs
50.00