Injectable Peptide-Based Hydrogel for Cartilage Regeneration and Light-Responsive Surgical Sealant for Rapid Dural Closure CSR Proposal

Injectable peptide-based hydrogel formulation to reverse cartilage degeneration in Arthritis Patients

Objective

• PROJECT 1: Develop a minimally invasive injectable hydrogel system to treat arthritis and other musculoskeletal disorders, promoting rapid recovery and regeneration of aged cartilage, reducing pain, and avoiding the need for prosthetic surgery. PROJECT 2: Synthesize a natural, light-responsive hydrogel sealant effective for providing watertight closure within seconds during spinal surgery to prevent cerebrospinal fluid leakage and complications.

Description

• PROJECT 1: Focus on addressing cartilage degradation in joints caused by aging, injuries, and wear and tear., Develop a peptide-based gel formulation with native cellular ingredients., Broad applications for arthritis and other severe cartilage disorders., Aims to efficiently reduce pain and promote tissue regeneration., Potential to significantly improve the quality of life for patients. PROJECT 2: Address the challenge of proper dural closure during spinal surgery., Develop a natural hydrogel-based sealant with key performance attributes., Ease of preparation, biocompatibility, mechanical strength, and biodegradability., Ensures watertight closure, tissue adherence, and compliance to wet tissue., Reduces economic burden and improves patient safety during surgery.

Impact

• not given